Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor II
A cell-permeable hydroxynaphthalenylthioacetate that targets Mcl-1 BH3-binding groove and selectively competes against 8nM FITC-AHA-BIM142-161 for Mcl-1, but not Bcl-xL, binding (IC50 = 310nM vs >40μM; [Mcl-1] & [Bcl-x
MilliporeSigma™ Calbiochem™ p38 MAP Kinase Inhibitor X, BIRB 796
The p38 MAP Kinase Inhibitor X, BIRB 796, also referenced under CAS 285983-48-4, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PI 3-K Inhibitor XXI, GDC-0941
A cell-permeable, potent, ATP-competitive inhibitor of class IA (IC50 = 3 nM/p110α, 33 nM/p110β, 3 nM/p110δ) and IB PI 3-kinases (IC50 = 75 nM/p110γ).
MilliporeSigma™ Calbiochem™ BMX/BTK Inhibitor II, QL47
A cell-permeable, highly potent, selective, irreversible inhibitor of BTK (IC50 = 6.6 nM).
MilliporeSigma™ Calbiochem™ InSolution™ TAPI-2
A 10 mM (1 mg/241 μL) sterile-filtered solution of TAPI-2 in H2O.
MilliporeSigma™ Calbiochem™ Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (≈10 to 40 μM).
MilliporeSigma™ Calbiochem™ MT1-MMP Inhibitor, NSC405020
The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Cdk1/2 Inhibitor II, NU6102
The Cdk1/2 Inhibitor II, NU6102, also referenced under CAS 444722-95-6, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ TAPI-1
InSolution™ TAPI-1, CAS 171235-71-5, is a 10mm solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
MilliporeSigma™ Calbiochem™ PI 3-Kα Inhibitor IV
The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps.
MilliporeSigma™ Calbiochem™ mTOR Inhibitor III, PP242
The mTOR Inhibitor III, PP242 controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Okadaic Acid, Potassium Salt
Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
MilliporeSigma™ Calbiochem™ W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 μM).